Cuban couple Esteban and his sick wife, Marina Hernandez, are pulled from the ocean during a dangerous rescue at sea while en route to the U.S. on a mission to reach Dr. House. Marina's medical records from Cuba were lost in the shipwreck, so the team runs a series of tests to determine the extent of her illness. When Marina's heart stops during a routine cardiac catheterization, the diagnostic mystery deepens. House debates with the team whether it was human error or a still-to-be-determined illness that caused Marina to flat-line, and the team fights to keep Marina alive on a bypass machine long enough for her husband to say goodbye, knowing that nothing short of a miracle can save her. Meanwhile, Foreman prepares for his last day of work at Princeton-Plainsboro, and Chase accuses House of trying to win Foreman over in order to dissuade him from leaving, prompting House to make a very rash decision that affects the whole team in the "Human Error" episode of House.