A famous, 42-year-old, pregnant photographer, Emma Sloan (guest star Anne Ramsay), is brought to the hospital after suffering a stroke in the middle of a high-profile photo shoot with Tyson Ritter (All American Rejects). Although Emma's condition initially stabilizes, her health takes a turn for the worse when her kidneys inexplicably fail. As her health continues to deteriorate, Emma is more concerned about her baby's well-being than her own. With no other viable explanation for the kidney failure, House realizes Emma may have a rare condition called Maternal Mirror Syndrome, in which the mother's health mimics the distress level of her fetus. Meanwhile, Cameron and Chase's secret relationship is exposed to Foreman and Cuddy, and House makes extravagant plans to take a much-needed vacation. House calls Cuddy on the fact she's taken a special interest in the case as she identifies with Emma's struggle to have a child later in life, but her compassion for Emma may be clouding her judgment in the case. When Emma's liver begins to fail, House presents her with the heart-wrenching choice to terminate her fetus or die herself. But with Cuddy on her side, Emma demands they come up with another option – an option that may not exist. With Cuddy and House at odds over how to handle her case, Emma faces a life-and-death situation for both herself and her unborn child.