Cells with clear endothelial morphology shown giving rise to blood cells. Left panel: phase contrast. Right panel: fluorescence detecting HIstone 2B-Venues expression. !st pause in video: single mesodermal cell starting the colony 2nd pause: all cells in the colony exhibit a clear endothelial sheet mrophology 3rd pause: some cells lose tight integration into the endothelial sheet but keep adhering to endothelial cells 4th pause: Blood cells detach and are free-floating. The arrow is following the starting cell and one daughter cell after each cell division until the end of the video Timescale: days hours:minutes:seconds Courtesy of Eilken et al.,