Watch the Video and Read the Article. Coronary artery disease affects over ten million people in the United States and is the leading cause of death in both men and women. Angina refers to symptoms that result from plaque narrowing coronary arteries. This is often described as pressure, tightness or burning in the chest that may occur during exercise. The discomfort may radiate to the left arm or jaw and often is accompanied by nausea, sweating ...